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Pyridam |  |
| Farma |
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Each caplet contains Trimethoprim 80 mg and Sulfamethoxazole 400 mg. Each forte caplet contains Trimethoprim 160 mg and Sulfamethoxazole 800 mg. PHARMACOLOGY : Cotrim contains 2 active ingredients acting sinergically by blockade of 2 enzymes that catalogue successive stages in the biosynthesis of folinic acid in the micro-organism. This mechanism usually results in bactericidal activity in-vitro in concentrations at which the individual components are only bacteriostatic. INDICATIONS : Renal and urinary tract infections : cystitis, pyelonephiritis, pyelitis, urethritis. Gastrointestinal tract infections : typhoid, paratyphoid and bacillary dysentery. Respiratory tract infections : toxoplasmosis etc which other drug of choice can not be administered. DOSAGE : To be taken twice daily ( morning and evening) Cotrim caplet : Adult : 2 caplet Children 6-12 year, 1 caplet. Cotrim forte caplet : Adult : 1 caplet Children 6-12 year : ½ caplet The recommended duration of therapy for urinary tract infections : 10-14 days and Shigellosis : 5 days. For severe infections, the dosage may be increased by 50 % in 3 divided dosage. SPECIAL DOSAGE INSTRUCTION : Patient with impaired kidney function : Creatinine clearance (ml/min) Recommended Dosage Schedule > 30 Standard dosage 15-30 Half of Standard dosage < 15 Use of Cotrim not recommended CONTRAINDICATIONS : Patients with marked liver parenchymal damage, also in patients with severe renal insufficiency when repeated determinations of the plasma concentration can not be made. Severe blood dyscrasia Hypersensitivity to components of Cotrim. Pregnancy. If pregnancy can not be excluded, possible risks should be weighed against the expected therapeutic effect. Nursing mother, premature and new of life born infants during 2 months of life. PRECAUTIONS : In the event of renal impairment dosage should be adjusted according to the special dosage instructions. If Cotrim is given over a prolonged period regular blood counts are required. If a significant reduction in the count of any formed blood element is noted. Cotrim should be discontinued. Treatment should be discontinued immediately at the first appearance of skin rash or any other serious adverse reaction. In elderly patients or in patients with pre-existing folic acid deficiency or kidney failure hematological changes indicative at folic acid deficiency may occur. These are reversible by folinic acid therapy. Cotrim is best taken after meals with an adequate amount of water. In infection of pharyngitis due to group A hematology streptococcus, the rate of eradication is not fully satisfactory. ADVERSE REACTIONS : Dermatology : skin rash Hematology : leucopenia, neutropenia and thrombocytopenia Very rarely : agranulocytosis, megaloblastic anemia, or Gastrointestinal : nausea ( with or without vomiting ) Others : syndrome Steven-Johnson and Lyelli. DRUG INTERACTIONS : Oral anti coagulant Increase the effect Hypoglycaemic agent Cotrim may also affect the required dose of hypoglycaemic drugs Pyrimethamin Patient receiving pyrimethamine as malaria prophylaxis in doses exceeding 25 mg weekly, may develop megalablastic anemia if Cotrim is prescribed concurrently. STORAGE : Store in a coal acid dry place far from reach of children Reg. No Cotrim : DKL8521000904B1 Cotrim forte : DKL9421000904C1 On medical prescription only. |
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