|Your Health is our Priority|
Each caplet of Xanturic – 100 contains 100 mg of allopurinol.
Each caplet of Xanturic – 300 contains 300 mg of allopurinol.
Allopurinol inhibits xanthine oxidase, the important enzyme which changes hypoxanthine to xanthine and from xanthine to uric
acid. Since allopurinol decreases urate formation, it reduces urate / uric acid concentrations in both body fluids and urine.
Allopurinol is used to reduce urate concentrations in body fluids and / or urine to prevent or reverse the deposition of urate /
uric acid : gouty arthritis, skin tophi and / or renal involvement through crystal deposition or stone formation.
Such clinical manifestations occur in : idiophatic, neoplastic disease, and myeloproliferative disease with high cell turnover
rates, in which high urate levels occur either spontaneously or after cytotoxic therapy.
Hypersensitivity to allopurinol
Patients who suffered from liver disease and bone marrow suppression.
Avoid the use of allopurinol in patients with renal insufficiency and asymptomatic hyperuricaemia.
The treatment should be withdrawn immediately when a skin rash or other evidence of sensitivity occurs.
Prolonged treatment may cause cataract.
ADVERSE REACTIONS :
The most common reactions that may occur : diarrhea, skin rash, fever, nausea, vomiting, headache, drowsiness.
When Mercaptopurine or Azathioprine is given by mouth concurrently with allopurinol, only ¼ of the usual dose of
Mercaptopurine or Azathioprine should be given, because inhibition of xanthine oxidase prolongs their activity.
Patients receiving anticoagulant must be carefully monitored.
Increases the toxicity of cyclophosphamide.
The dosage should be adjusted by monitoring serum urate concentrations and urinary urate/uric acid levels at appropriate
Adult initial dose : 100 mg daily, each week increase 100 mg daily up until the optimal effect is achieved. Maximal
dose is 800 mg daily.
Dosage recommendations in renal disorders : 100 – 200 mg daily.
Children < 6 years : maximal dose 150 mg daily.
Keep in a cool and dry place.
Xanturic – 100. Box of 5 x 10’s caplets. Reg. No. DKL9221005704A1
Xanturic – 300. Box of 5 x 10’s caplets. Reg. No. DKL9221005704B1
On Medical Prescription Only.