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Each capsul contains 50 mg and 100 mg Doxycycline ( as HCl )
Microbiology : Viadoxin acts bacteriostatically by inhibiting the protein synthesis of the microorganism . The tetracyclines,
including Viadoxin, have the widest antimicrobial spectrum of all chemotherapeutics.
Some of the most, sensitive bacteria are Strptococcus haemolyticus, Diplococcus pneumoniae, Stretococcus viridans, Neiserria
meningitidis, Neiserria gonorrhoea, Clostridium, Brucella and Leptospira spp and Treponema pallidum. Bacteria that are less
sensitive to Viadoxin are Stapylococcus aureus, E. coli, Klesiella, Enterobacter, Salmonella, Shigella and Yersinia spp,
Haemophilus influenzae, Bordetella pertussis, Bacillus and Bacteroides spp. More over, Viadoxin has an effect on Rickettsia,
Chlamydia and Mycoplasma spp; resistance is seen in Streptococcus faecalis, Pseudomonas aeruginosa and in most Proteus
sp . Resistance develops relatively easily. The incidence of resistant bacteria is presumed to be in proportion to the widespread
use of tetracycline treatment.
Pharmacokinetics : After oral intake, Viadoxin is absorbed almost completely. In contrast to other tetracyclines, foods ( milk
products ) only affect oral absorption to a very low degree Maximal plasma concentration of 3 g/ml is obtained within 2 hrs
after the intake of 200 mg and 25-30% of the absorbed Viadoxin is bound to plasma proteins. Viadoxin passed the placental
barrier and is present in breast milk. Viadoxin is eliminated by glomerular filtration ( about 10% ) and by the faeces ( about
90% ). Viadoxin undergoes enterohepatic circulation and high concentrations are obtained in the bile. The biological half – life
is about 20 hrs. However, the time of elimination is only slightly affected by reduced renal function.
Treatment of a variety of infections of the gastro-urinary tract, respiratory tract and soft tissues.
DOSAGE & ADMINISTRATION :
Adult: 100 mg twice daily during the first 24 hrs, thereafter 100 mg every 24 hrs. For severe Infections: 200 mg daily.
Children: 4mg/kg body weight, twice during the first 24 hrs, thereafter 2mg/kg body weight once every 24 hrs. For
severe Infections: 4 mg/kg body weight daily. The dose must be reduced in liver insufficiency and also in cases of
severely reduced renal function. In long term treatment (>6 days ), the serum concentration must be checked.
Acute Gonorrhoea: 300 mg single dose or 200 mg daily for 7 days.
NGU: 200 mg daily for 10 days. To avoid side effect, it is recommended to administer Viadoxin in connection with meals.
Hypersensitivity to tetracyclines; renal dysfunction.
Like other tetracycline derivatives, Viadoxin may cause tooth discoloration if given to children < 8 years, or administered during
the last 5 months of pregnancy. It is not recommended during lactation and for children < 8 years due to possibility of
SIDE EFFECTS :
Malaise, vomiting, diarrhea, dermatitis and allergic manifestation may occur occasionally. Superinfections caused by Viadoxin
resistant microorganism are seen in rare cases, as with other antibiotic treatment: Glossitis, stomatitis and proctitis. A few
sensitive patients may develop photosensitivity on exposure to sunlight. In contrast to other tetracyclines, Viadoxin does not
accumulate in patients with renal insufficiency. The tetracyclines are deposited in tooth enamel and bone tissues and may
bring about tooth discoloration and enamel dysplasia, although this tendency is low for Viadoxin owing to a poorer affinity to
Absorption of orally administered tetracycline may be reduced by concurrent intake of milk and minerals like Ca, Al, Mg, Fe and
NaHCO3. However, Viadoxin administered concurrently with milk products only affect oral absorption to a very low deggre. Oral
and parenteral tetracyclines administered concurrently with diuretics and methoxyflurane may cause renal disturbances.
Capsule 50 mg. Bottle of 50’s. Reg.No.DKL9421007701A1.
Capsule 100 mg. Box of 10x10’s. Reg.No.DKL8521000501A1.
On medical prescription only