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LOCHOL
Capsule
COMPOSITION  :
Each capsule of Lochol – 300 contains 300 mg of gemfibrozil.

PHARMACOLOGY  :
Lochol is a lipid regulating agent which reduces total cholesterol, LDL cholesterol, VLDL and triglycerides and increases HDL
cholesterol.
Lochol mechanism of action has not been definitely established. In man, it inhibitis peripheral lipolysis and decreases the
hepatic extraction of free fattyacids. It also inhibits synthesis and increases clearance of apolipoprotein B which is a carrier of
VLDL leading to a decrease in VLDL production.

PHARMACOKINETICS  :
Lochol is well absorbed from the gastrointestinal tract after oral administration. Peak plasma levels occur in 1-2 hrs with
plasma half – life of 1,5 hrs following multiple doses.
Lochol undergoes oxidation of a ring methyl group to form successively a hydroxymethyl and a carboxyl metabolite.
Approximately 70 % of the administered human dose is excreted in the urine, mostly as the glucuronide conjugate with < 2 %
excreted as the unchanged gemfibrozil. 6 % of the dose is accounted for in the feces.

INDICATIONS  :
Treatment of patients with hypercholesterolemia, mixed dyslipidemia and hypertriglyceridemia, Frederickson’s classification
types IIa, Iib and IV, respectively for the prevention of coronary heart disease (CHD). Treatment of other dyslipidemias  :
Frederickson types III and IV ; associated with diabetes ; associated with xanthoma.

CONTRAINDICATIONS  :
Patients with severe hepatic or severe renal dysfunction, preexisting  gallbladder disease ; patients who are hypersensitive to
Lochol ; primary biliary cirrhosis.

PRECAUTIONS  :
Periodic determinations of serum lipids should be obtained during treatment with Lochol.
There have been reports of severe myositis with markedly elevated creatinine kinase and myoglobinuria (rhabdomyolysis)
when Lochol and lovastatin were used concomitantly
Safety in pregnancy and nursing mothers has not been established safety and efficacy of Lochol in children have not been
established.

SIDE EFFECTS  :
Reported adverse reactions mostly encountered : dyspepsia, abdominal pain, acute appendicitis, atrial fibrillation,
diarrhea, nausea, epigastric pain, vomiting.
Adverse event rarely are rash, dermatitis, pruritus, urticaria, impotence, headache, blurred vision.

INTERACTIONS  :
Caution should be exercised when anticoagulants are given in conjunction with Lochol. The dosage of the anticoagulant should
be reduced to maintain the prothrombin time at the desired level to prevent bleeding complications. Frequent prothrombin
time determinations are advisable until it has been definitely determined that the prothrombin time level has stabilized.

PACKING :
Lochol – 300  capsules in boxes of 10 x 10’s     Reg. No. DKL 9021004601A1

STORAGE  :
Keep in a cool and dry place

ON DOCTOR’S PRESCRIPTION ONLY



.

High Standard
Pyridam is Certified in  Good
Manufacturing Practices
(GMP).

Our Products have met the
International Level and
Requirement.

How to contact us
for more information

email: info@pyridam.com
Phone: +62-21-536-90112
Fax     : +62-21-532-9049